A method of controlling uplink power in a wireless communication system includes receiving a power control message including parameters for uplink power control from a base station, and controlling uplink power based on the power control message, wherein the uplink power is determined according to a target SINR (Signal to Interference plus Noise Ratio), the target SINR is determined by a minimum rate SINR required at the base station and a control factor for noise and interference. Transmission power of signal can be more accurately controlled and an influence of an inter-cell interference or a path loss can be reduced to thus improve quality of service of the wireless communication system.