A multi-node communication system and method used to request, report and collect destination-node-based measurements and route-based measurements is disclosed. The communication system may be a mesh network including a plurality of mesh points (MPs). In one embodiment, a destination-node-based measurement request is sent to one or more destination nodes via destination-unicast, destination-multicast, or destination-broadcast, using routes specified via next-hop-unicast, next-hop-multicast, or next-hop-broadcast addressing. In another embodiment, a source node sends a measurement request message to a final destination node, whereby each node along the route individually sends a measurement report message to the source node. Alternatively, measurement results of each node are combined and appended to the measurement request message, and a measurement report message including the combined measurement results is sent to the source node.