A Cartesian coordinate robot includes a first transmission mechanism slidably connected to a second transmission mechanism, a third transmission mechanism slidably connected to the second transmission mechanism. The first transmission mechanism includes a first guide rail, a first slider slidably connected to the first guide rail, and a first driving module driving the first slider. The second transmission mechanism includes a second guide rail perpendicular to the first guide rail, a second slider slidably connected to the second guide rail, and a second driving module driving the second slider. The third transmission mechanism includes a third guide rail perpendicular to the first guide rail and the second rail, a third slider slidably connected to the third guide rail, and a third driving module driving the third slider.