A ball valve isolator (5) includes a housing (15), a ball valve (60), a first isolator (40), and a second isolator (41). The housing (15) is provided with a first flow passage (29) located between an inlet (30) and an outlet (31). The ball valve (60) that includes a ball portion (63) located in the first flow passage (29) and defines a second flow passage (65) that is aligned with the first flow passage (29) when the ball valve (60) is actuated to an open position. The first isolator (40) is located, at least in part, within the housing (15) and substantially blocks the inlet (30) when the first isolator (40) is actuated to a closed position. The second isolator (41) is located, at least in part, within the housing (15) and substantially blocks the outlet (31) when the second isolator (41) is actuated to a closed position.