Invention Grant
- Patent Title: Biologically active nanoparticles a carbonate-substituted hydroxyapatite, process for their preparation and compositions incorporating the same
- Patent Title (中): 生物活性纳米颗粒碳酸酯取代的羟基磷灰石,其制备方法和包含其的组合物
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Application No.: US11916022Application Date: 2006-05-30
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Publication No.: US08367043B2Publication Date: 2013-02-05
- Inventor: Giancarlo Gazzaniga , Norberto Roveri , Lia Rimondini , Barbara Palazzo , Michele Iafisco , Paolo Gualandi
- Applicant: Giancarlo Gazzaniga , Norberto Roveri , Lia Rimondini , Barbara Palazzo , Michele Iafisco , Paolo Gualandi
- Applicant Address: IT Funo di Argelato (BO)
- Assignee: Coswell S.p.A.
- Current Assignee: Coswell S.p.A.
- Current Assignee Address: IT Funo di Argelato (BO)
- Agency: Steinfl & Bruno LLP
- International Application: PCT/EP2006/005146 WO 20060530
- International Announcement: WO2007/137606 WO 20071206
- Main IPC: A61K6/00
- IPC: A61K6/00 ; A61K6/033 ; A61K9/14 ; A61Q11/00 ; C01F11/00

Abstract:
The invention relates to biologically active nanoparticles of a carbonate-substituted non-stoichiometric hydroxyapatite, having: a) a crystallinity degree CD lower than 40%, the crystallinity degree being defined as CD=(1−X/Y)·100 wherein: Y=height of the diffraction maximum at 2θ=33°, X=height of the diffraction background at 2θ=33° of the nanoparticles X-ray diffraction pattern; b) a length L ranging from 20 to 200 nm and a width W ranging from 5 to 30 nm; and c) an aspect ratio AR comprised between 2 and 40, the aspect ratio being defined as AR=L/W. The biologically active nanoparticles of the invention find a preferred use in oral or dental hygiene applications and may be formulated as compositions for oral or dental hygiene such as, for example, solutions, suspensions, oils, gels or other solid products. Other aspects of the invention include a process for preparing a suspension for oral or dental hygiene including the aforementioned biologically active nanoparticles, a process for manufacturing a toothpaste comprising the nanoparticles, as well as a method of locally remineralizing the teeth comprising contacting the teeth with the nanoparticles.
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