Invention Grant
- Patent Title: Glycopeptides derived from pancreatic structures, antibodies and applications thereof in diagnostics and therapeutics
- Patent Title (中): 衍生自胰腺结构的糖肽,抗体及其在诊断和治疗中的应用
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Application No.: US12488793Application Date: 2009-06-22
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Publication No.: US08367062B2Publication Date: 2013-02-05
- Inventor: Dominique Lombardo , Eric Mas , Marie-Odile Sadoulet , Laurence Panicot-Dubois , Jean-Paul Bernard
- Applicant: Dominique Lombardo , Eric Mas , Marie-Odile Sadoulet , Laurence Panicot-Dubois , Jean-Paul Bernard
- Applicant Address: FR Marseilles Cedex
- Assignee: Universite d'Aix-Marseille
- Current Assignee: Universite d'Aix-Marseille
- Current Assignee Address: FR Marseilles Cedex
- Agency: Saliwanchik, Lloyd & Eisenschenk
- Priority: FR0403378 20040331; FR0413428 20041216
- Main IPC: A61K39/395
- IPC: A61K39/395

Abstract:
Glycopeptide comprising 1 to 40 repeated C-terminal polypeptides, with 11 amino acids, of BSDL or FAPP, whereby said polypeptides are glycosylated and bear glycosylated epitopes giving rise to a specific immunological reaction with induced antibodies in a patient suffering from type 1 diabetes and/or purified from biological fluids of human or animal origin or recombinant and produced by expression in a standard host cell comprising an enzymatic material necessary for priming a glycosylation, said host cell being genetically modified such as to comprise a gene coding for said polypeptides and a gene coding for one or more enzymes selected from among glycosyltransferases, anti-glycopeptide antibodies and the applications thereof in therapeutics and diagnostics.
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