Invention Grant
US08367062B2 Glycopeptides derived from pancreatic structures, antibodies and applications thereof in diagnostics and therapeutics 有权
衍生自胰腺结构的糖肽,抗体及其在诊断和治疗中的应用

Glycopeptides derived from pancreatic structures, antibodies and applications thereof in diagnostics and therapeutics
Abstract:
Glycopeptide comprising 1 to 40 repeated C-terminal polypeptides, with 11 amino acids, of BSDL or FAPP, whereby said polypeptides are glycosylated and bear glycosylated epitopes giving rise to a specific immunological reaction with induced antibodies in a patient suffering from type 1 diabetes and/or purified from biological fluids of human or animal origin or recombinant and produced by expression in a standard host cell comprising an enzymatic material necessary for priming a glycosylation, said host cell being genetically modified such as to comprise a gene coding for said polypeptides and a gene coding for one or more enzymes selected from among glycosyltransferases, anti-glycopeptide antibodies and the applications thereof in therapeutics and diagnostics.
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