Invention Grant
US08367069B2 Cytotoxic T cell defined EGFR peptide and an optimized derivative peptide
有权
细胞毒性T细胞定义EGFR肽和优化的衍生肽
- Patent Title: Cytotoxic T cell defined EGFR peptide and an optimized derivative peptide
- Patent Title (中): 细胞毒性T细胞定义EGFR肽和优化的衍生肽
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Application No.: US12959073Application Date: 2010-12-02
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Publication No.: US08367069B2Publication Date: 2013-02-05
- Inventor: Robert L. Ferris , Pedro Andrade , Andres Lopez-Albaitero
- Applicant: Robert L. Ferris , Pedro Andrade , Andres Lopez-Albaitero
- Applicant Address: US PA Pittsburgh
- Assignee: University of Pittsburgh—of the Commonwealth System of Higher Education
- Current Assignee: University of Pittsburgh—of the Commonwealth System of Higher Education
- Current Assignee Address: US PA Pittsburgh
- Agency: Leydig, Voit & Mayer, Ltd.
- Main IPC: C07K11/00
- IPC: C07K11/00 ; A61K39/39 ; A61K38/08 ; A61K39/12 ; C07K14/71
Abstract:
The invention provides a polypeptide having a sequence of amino acids consisting of IXDFGLAKL (SEQ ID NO: 1), as well as a nucleic acid encoding the polypeptide, vector comprising the nucleic acid, cell comprising the vector, and compositions thereof. The invention also provides a method of inducing a T-cell response in a patient with epithelial cancer, and a method inhibiting epithelial cancer, wherein the methods comprise administering the composition of the invention. The invention further provides a method of stimulating a cell with the inventive polypeptide and a cell so stimulated.
Public/Granted literature
- US20110171170A1 CYTOTOXIC T CELL DEFINED EGFR PEPTIDE AND AN OPTIMIZED DERIVATIVE PEPTIDE Public/Granted day:2011-07-14
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