Invention Grant
US08367074B2 Recovery of recombinant human parainfluenza virus type 2 (HYPIV2) from cDNA and use of recombinant HPIV2 in immunogenic compositions and as vectors to elicit immune responses against PIV and other human pathogens
有权
从cDNA中恢复2型重组人副流感病毒（HYPIV2），并在免疫原性组合物中使用重组HPIV2，并作为引导针对PIV和其他人类病原体的免疫应答的载体
- Patent Title: Recovery of recombinant human parainfluenza virus type 2 (HYPIV2) from cDNA and use of recombinant HPIV2 in immunogenic compositions and as vectors to elicit immune responses against PIV and other human pathogens
- Patent Title (中): 从cDNA中恢复2型重组人副流感病毒（HYPIV2），并在免疫原性组合物中使用重组HPIV2，并作为引导针对PIV和其他人类病原体的免疫应答的载体
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Application No.: US11863196Application Date: 2007-09-27
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Publication No.: US08367074B2Publication Date: 2013-02-05
- Inventor: Mario H. Skiadopoulos , Brian R. Murphy , Peter L. Collins
- Applicant: Mario H. Skiadopoulos , Brian R. Murphy , Peter L. Collins
- Applicant Address: US DC Washington
- Assignee: The United States of America as represented by the Secretary of the Department of Health & Human Services
- Current Assignee: The United States of America as represented by the Secretary of the Department of Health & Human Services
- Current Assignee Address: US DC Washington
- Agency: Woodcock Washburn LLP
- Main IPC: A61K39/155
- IPC: A61K39/155 ; C07H23/00 ; C07K14/00
Abstract:
Recombinant human parainfluenza virus type 2 (HPIV2) viruses and related immunogenic compositions and methods are provided. The recombinant HPIV2 viruses, including HPIV2 chimeric and chimeric vector viruses, provided according to the invention are infectious and attenuated in permissive mammalian subjects, including humans, and are useful in immunogenic compositions for eliciting an immune responses against one or more PIVs, against one or more non-PIV pathogens, or against a PIV and a non-PIV pathogen. Also provided are isolated polynucleotide molecules and vectors incorporating a recombinant HPIV2 genome or antigenome.
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