Invention Grant
- Patent Title: Methods for determining signal transduction activity in tumors
- Patent Title (中): 确定肿瘤信号转导活性的方法
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Application No.: US12299699Application Date: 2007-05-07
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Publication No.: US08367351B2Publication Date: 2013-02-05
- Inventor: Mark Gustavson , Jennifer Giltnane , Marisa P. Dolled-Filhart , Robert L. Camp , David L. Rimm
- Applicant: Mark Gustavson , Jennifer Giltnane , Marisa P. Dolled-Filhart , Robert L. Camp , David L. Rimm
- Applicant Address: US CT New Haven US CT New Haven
- Assignee: Historx, Inc.,Yale University
- Current Assignee: Historx, Inc.,Yale University
- Current Assignee Address: US CT New Haven US CT New Haven
- Agency: Cooper & Dunham LLP
- Agent John P. White
- International Application: PCT/US2007/011052 WO 20070507
- International Announcement: WO2007/130677 WO 20071115
- Main IPC: G01N33/53
- IPC: G01N33/53 ; G01N31/00
Abstract:
The method of the invention pertains to determining the signal transduction activity in a tissue section by immunohistochemistry techniques. The expression level of the receptor of interest is determined as well as the expression levels of one or more effector molecules of the receptor signal transduction pathway. Furthermore a combined ratio of expression levels of effector molecules in subcellular compartments with the receptor expression was found to have prognostic significance.
Public/Granted literature
- US20100062452A1 METHODS FOR DETERMINING SIGNAL TRANSDUCTION ACTIVITY IN TUMORS Public/Granted day:2010-03-11
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