Invention Grant
- Patent Title: Methods for producing human ceramide using yeast transformants
- Patent Title (中): 使用酵母转化体生产人神经酰胺的方法
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Application No.: US12663232Application Date: 2008-05-20
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Publication No.: US08367375B2Publication Date: 2013-02-05
- Inventor: Yukiko Kodama , Hiroaki Okuhara , Koichi Funato
- Applicant: Yukiko Kodama , Hiroaki Okuhara , Koichi Funato
- Applicant Address: JP Osaka-shi, Osaka JP Higashi-Hiroshima-shi, Hiroshima
- Assignee: Suntory Holdings Limited,Hiroshima University
- Current Assignee: Suntory Holdings Limited,Hiroshima University
- Current Assignee Address: JP Osaka-shi, Osaka JP Higashi-Hiroshima-shi, Hiroshima
- Agency: Drinker Biddle & Reath LLP
- Priority: JP2007-149657 20070605
- International Application: PCT/JP2008/059241 WO 20080520
- International Announcement: WO2008/149665 WO 20081211
- Main IPC: C12P21/00
- IPC: C12P21/00 ; C12N1/19
Abstract:
The present invention provides a method for producing human ceramide in a yeast cell.The method of the present invention comprises: 1) introducing the sphingoid Δ4-desaturase gene (DES1) by transformation of the yeast cell; 2) abolishing the expression of the yeast sphinganine C4-hydroxylase gene (SUR2) by transformation of the yeast cell; and 3) abolishing the expression of the yeast sphingoid base kinase gene (LCB4) by transformation of the yeast cell.
Public/Granted literature
- US20100304467A1 METHODS FOR PRODUCING HUMAN CERAMIDE USING YEAST TRANSFORMANTS Public/Granted day:2010-12-02
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