Invention Grant
- Patent Title: Methods for determining dysregulation of methylation of brain expressed genes on the X chromosome to diagnose autism spectrum disorders
- Patent Title (中): 确定X染色体上脑表达基因甲基化失调的诊断自闭症谱系障碍的方法
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Application No.: US13170795Application Date: 2011-06-28
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Publication No.: US08367417B2Publication Date: 2013-02-05
- Inventor: Roger E. Stevenson , Julie R. Jones , Cindy D. Skinner , Michael J. Friez
- Applicant: Roger E. Stevenson , Julie R. Jones , Cindy D. Skinner , Michael J. Friez
- Applicant Address: US SC Greenwood
- Assignee: Greenwood Genetic Center, Inc.
- Current Assignee: Greenwood Genetic Center, Inc.
- Current Assignee Address: US SC Greenwood
- Agency: Dority & Manning, P.A.
- Main IPC: C12Q1/68
- IPC: C12Q1/68
Abstract:
The discovery that alterations in methylation, which can cause one or more genes on the single X chromosome in males to be partially silenced or overexpressed, constitute a predisposition to autism spectrum disorders is generally disclosed herein. These alterations provide the rationale and basis for methods to diagnose autism spectrum disorders.
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