Invention Grant
- Patent Title: Quinolone derivative
- Patent Title (中): 喹诺酮衍生物
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Application No.: US12680301Application Date: 2008-09-25
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Publication No.: US08367702B2Publication Date: 2013-02-05
- Inventor: Kenichi Onda , Kenichiro Imamura , Fumie Sato , Hiroyuki Moritomo , Yasuharu Urano , Yuki Sawada , Naoki Ishibashi , Keita Nakanishi , Kazuhiro Yokoyama , Shigetada Furukawa , Kazuhiro Momose
- Applicant: Kenichi Onda , Kenichiro Imamura , Fumie Sato , Hiroyuki Moritomo , Yasuharu Urano , Yuki Sawada , Naoki Ishibashi , Keita Nakanishi , Kazuhiro Yokoyama , Shigetada Furukawa , Kazuhiro Momose
- Applicant Address: JP Tokyo
- Assignee: Astellas Pharma Inc.
- Current Assignee: Astellas Pharma Inc.
- Current Assignee Address: JP Tokyo
- Agency: Oblon, Spivak, McClelland, Maier & Neustadt, L.L.P.
- Priority: JP2007-248877 20070926
- International Application: PCT/JP2008/067325 WO 20080925
- International Announcement: WO2009/041521 WO 20090402
- Main IPC: A61K31/04
- IPC: A61K31/04 ; C07D215/38
Abstract:
As a result of extensive studies on NAD(P)H oxidase inhibitors, the present inventors found that a quinolone derivative having, at the 2-position, an alkyl group substituted with a heteroatom or the like has an excellent NAD(P)H oxidase inhibitory activity, and accomplished the present invention. The compound of the present invention has a reactive oxygen species production inhibitory activity based on the NAD(P)H oxidase inhibitory activity, and therefore can be used as an agent for preventing and/or treating diabetes, impaired glucose tolerance, hyperlipidemia, fatty liver, diabetic complications and the like.
Public/Granted literature
- US20100256113A1 QUINOLONE DERIVATIVE Public/Granted day:2010-10-07
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