Invention Grant
- Patent Title: Angiotensin II receptor antagonists
- Patent Title (中): 血管紧张素II受体拮抗剂
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Application No.: US13483213Application Date: 2012-05-30
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Publication No.: US08367711B2Publication Date: 2013-02-05
- Inventor: Amjad Ali , Michael Man-Chu Lo , Christopher Franklin , Iyassu K. Sebhat , Nicoletta Almirante , Silvia Stefanini , Stefano Biondi , Ennio Ongini
- Applicant: Amjad Ali , Michael Man-Chu Lo , Christopher Franklin , Iyassu K. Sebhat , Nicoletta Almirante , Silvia Stefanini , Stefano Biondi , Ennio Ongini
- Applicant Address: US NJ Rahway
- Assignee: Merck Sharp & Dohme Corp.
- Current Assignee: Merck Sharp & Dohme Corp.
- Current Assignee Address: US NJ Rahway
- Agent Richard S. Parr; Catherine D. Fitch
- Main IPC: A61K31/41
- IPC: A61K31/41 ; A61K31/405 ; C07D209/00 ; C07D257/04
Abstract:
A compound having the structure wherein R is, for example, Y is selected from the group consisting of 1) R5, 2) —C(R1R2) (C(R3R4))0-1Y1R5, and 3) —C(R1R2)—O—Y1R5; R1, R2, R3 and R4 are independently selected from the group consisting of hydrogen and C1-4 alkyl; R5 is; Y1 is selected from the group consisting of C(O)—O— and P(O)(OR6)—O—; and R6 is hydrogen or CH3, or a pharmaceutically acceptable salt thereof, and methods of using the compounds for treating hypertension.
Public/Granted literature
- US20120238608A1 ANGIOTENSIN II RECEPTOR ANTAGONISTS Public/Granted day:2012-09-20
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