Invention Grant
- Patent Title: Process for preparing Montelukast and salts thereof
- Patent Title (中): 制备孟鲁司特及其盐的方法
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Application No.: US13474135Application Date: 2012-05-17
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Publication No.: US08367834B2Publication Date: 2013-02-05
- Inventor: Venkata Sunil Kumar Indukuri , Srinivas Simhadri , Satyanarayana Chava
- Applicant: Venkata Sunil Kumar Indukuri , Srinivas Simhadri , Satyanarayana Chava
- Applicant Address: IN Hyderabad
- Assignee: Laurus Labs Private Limited
- Current Assignee: Laurus Labs Private Limited
- Current Assignee Address: IN Hyderabad
- Agency: Blank Rome LLP
- Priority: IN1284/CHE/2008 20080526
- Main IPC: C07D215/18
- IPC: C07D215/18
Abstract:
A method for the preparation of montelukast and salts thereof has been described. The method comprises of following steps: (a) (S)-1-(3-((E)-2-(7-chloroquinolin-2-yl)vinyl)phenyl)-3-(2-isopropenylphenyljpropyl methane sulphonate (styrene mesylate salt) (b) coupling with 1-(mercaptomethyl)cyclopropane acetic acid followed by salification with an amine gives styrene amine salt (c) Converting styrene amine salt to Montelukast amine salt (d) Converting Montelukast amine salt to Montelukast free acid and or its required alkali/alkaline salt.
Public/Granted literature
- US20120232276A1 PROCESS FOR PREPARING MONTELUKAST AND SALTS THEREOF Public/Granted day:2012-09-13
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