Invention Grant
- Patent Title: Process for the preparation of amorphous calcium salt of atorvastatin
- Patent Title (中): 阿托伐他汀无定形钙盐的制备方法
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Application No.: US10552562Application Date: 2004-04-09
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Publication No.: US08367848B2Publication Date: 2013-02-05
- Inventor: Ljubomir Antoncic , Gorazd Sorsak , Anton Copar
- Applicant: Ljubomir Antoncic , Gorazd Sorsak , Anton Copar
- Applicant Address: SI Ljubljana
- Assignee: LEK Pharmaceuticals D.D.
- Current Assignee: LEK Pharmaceuticals D.D.
- Current Assignee Address: SI Ljubljana
- Agency: Merchant & Gould P.C.
- Priority: SI200300100 20030411; SI200300138 20030606
- International Application: PCT/SI2004/000019 WO 20040409
- International Announcement: WO2004/089895 WO 20041021
- Main IPC: C07D207/34
- IPC: C07D207/34
Abstract:
Present invention refers to the process of preparing amorphous atorvastatin calcium without intermediate isolation of crystal or undefined mixture of crystal and amorphous atorvastatin calcium, respectively. Forming of calcium atorvastatin salt is carried out in a mixture of chlorinated organic solvent or cyclic hydrocarbon solvent, respectively, the non-hydroxylic organic solvent, and water, the source of calcium ions is calcium acetate or calcium chloride, respectively.
Public/Granted literature
- US20060287538A1 Process for the preparation of amorphous calcium salt of atorvastatin Public/Granted day:2006-12-21
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