The present invention discloses a method of processing a generic framing procedure (GFP) frame, the method includes the steps of: processing the GFP frame by the compensating process of payload area descrambler error multiplication factor; and processing the GFP frame by the process of tHEC or/and eHEC single-bit error correction. According to the present invention, not only a tHEC or/and eHEC single-bit error can be corrected, but also the tHEC or/and eHEC additional single-bit error can also be corrected so that the equipment's dependability and capability of anti-interference are improved significantly.