A method and computer program product for controlling application of ink in a printing press include predefining a setpoint color value in a device-independent color space. An ink metering element is activated with an ink application value, producing an ink layer thickness, on printing material, associated with the setpoint color value. An actual color value from the ink layer thickness on the printing material is determined, measured or colorimetrically measured in the device-independent color space. Activation with a changed ink application value based on deviation of the actual color value from the setpoint color value, produces an ink layer thickness differing from the produced ink layer thickness. A necessary ink layer thickness change is calculated based on changes in the color values in the device-independent color space upon a change in the ink layer thickness at the point of the actual color value, to determine the changed ink application value.