A unique landing nipple has spaced control line connections and external control lines running from the surface to those connections. A hydraulic barrier valve, such as a ball valve, is run in to a predetermined landing nipple and latched in position where the control line connections are in the right locations to operate the valve. A landing nipple with a latching groove alone can be used with a wireline run barrier valve to latch it into position at the desired location. A shifting tool is used to operate the mechanically actuated valve. More than one valve can be positioned or used in the string at a time or the same valve can also be positioned at different landing nipples at different times to meet the production needs of the well operator.