Invention Grant
- Patent Title: Rare cell analysis using sample splitting and DNA tags
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Application No.: US11763421Application Date: 2007-06-14
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Publication No.: US08372584B2Publication Date: 2013-02-12
- Inventor: Daniel Shoemaker , Mehmet Toner , Ravi Kapur , Roland Stoughton
- Applicant: Daniel Shoemaker , Mehmet Toner , Ravi Kapur , Roland Stoughton
- Applicant Address: US MA Boston US VA Richmond US CA Redwood City
- Assignee: The General Hospital Corporation,GPB Scientific, LLC,Verinata Health, Inc.
- Current Assignee: The General Hospital Corporation,GPB Scientific, LLC,Verinata Health, Inc.
- Current Assignee Address: US MA Boston US VA Richmond US CA Redwood City
- Agency: Fish & Richardson P.C.
- Main IPC: C12Q1/68
- IPC: C12Q1/68 ; G01N33/48

Abstract:
The present invention provides systems, apparatuses, and methods to detect the presence of fetal cells when mixed with a population of maternal cells in a sample and to test fetal abnormalities, e.g. aneuploidy. The present invention involves labeling regions of genomic DNA in each cell in said mixed sample with different labels wherein each label is specific to each cell and quantifying the labeled regions of genomic DNA from each cell in the mixed sample. More particularly the invention involves quantifying labeled DNA polymorphisms from each cell in the mixed sample.
Public/Granted literature
- US20080220422A1 RARE CELL ANALYSIS USING SAMPLE SPLITTING AND DNA TAGS Public/Granted day:2008-09-11
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