Invention Grant
- Patent Title: MCM6 and MCM7 monoclonal antibodies and methods for their use in the detection of cervical disease
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Application No.: US13247614Application Date: 2011-09-28
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Publication No.: US08372591B2Publication Date: 2013-02-12
- Inventor: Douglas P. Malinowski , Timothy J. Fischer , Adriann J. Taylor
- Applicant: Douglas P. Malinowski , Timothy J. Fischer , Adriann J. Taylor
- Applicant Address: US NC Burlington
- Assignee: Tripath Imaging, Inc.
- Current Assignee: Tripath Imaging, Inc.
- Current Assignee Address: US NC Burlington
- Agency: Alston & Bird LLP
- Main IPC: G01N33/577
- IPC: G01N33/577

Abstract:
Compositions and methods for diagnosing high-grade cervical disease in a patient sample are provided. The compositions include novel monoclonal antibodies, and variants and fragments thereof, that specifically bind to MCM6 or MCM7. Monoclonal antibodies having the binding characteristics of an MCM6 or MCM7 antibody of the invention are further provided. Hybridoma cell lines that produce an MCM6 or MCM7 monoclonal antibody of the invention are also disclosed herein. The compositions find use in practicing methods for diagnosing high-grade cervical disease comprising detecting overexpression of MCM6, MCM7, or both MCM6 and MCM7 in a cervical sample from a patient. Kits for practicing the methods of the invention are further provided. Polypeptides comprising the amino acid sequence for an MCM6 or an MCM7 epitope and methods of using these polypeptides in the production of antibodies are also encompassed by the present invention.
Public/Granted literature
- US20120015375A1 MCM6 AND MCM7 MONOCLONAL ANTIBODIES AND METHODS FOR THEIR USE IN THE DETECTION OF CERVICAL DISEASE Public/Granted day:2012-01-19
Information query
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