Invention Grant
- Patent Title: Asbestos detection method, asbestos detection agent, asbestos detection kit, method for screening candidate for agent aiming at preventing or treating disease for which asbestos is causative or worsening factor
- Patent Title (中): 石棉检测方法，石棉检测剂，石棉检测试剂盒，筛选候选药物的方法，旨在预防或治疗石棉致病或恶化的疾病
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Application No.: US12093316Application Date: 2006-11-08
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Publication No.: US08372596B2Publication Date: 2013-02-12
- Inventor: Akio Kuroda , Kazutaka Nomura
- Applicant: Akio Kuroda , Kazutaka Nomura
- Applicant Address: JP Higashihiroshima-Shi
- Assignee: National University of Corporation Hiroshima University
- Current Assignee: National University of Corporation Hiroshima University
- Current Assignee Address: JP Higashihiroshima-Shi
- Agency: Morrison & Foerster LLP
- Priority: JP2005-326502 20051110; JP2006-005061 20060112; JP2006-135674 20060515; JP2006-203983 20060726
- International Application: PCT/JP2006/322279 WO 20061108
- International Announcement: WO2007/055243 WO 20070518
- Main IPC: G01N33/00
- IPC: G01N33/00
Abstract:
The present invention provides a prompt and easy asbestos detection method and a method for screening a candidate for an agent aiming at preventing or treating a disease for which asbestos is a causative or worsening factor. It is possible to quickly and easily detect asbestos in a sample by finding a protein capable of binding specifically to asbestos, allowing the protein or a fusion protein of the protein and a reporter protein to bind to asbestos in the sample, and then detecting the protein or the fusion protein having been bound to asbestos. A substance inhibiting the binding of actin to asbestos, which has been found out as a protein capable of binding specifically to asbestos, is a candidate for an agent aiming at preventing or treating a disease for which asbestos is a causative or worsening factor.
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