Invention Grant
US08372802B2 Fluorinated macrocyclic compounds as hepatitis C virus inhibitors
有权
氟化大环化合物作为丙型肝炎病毒抑制剂
- Patent Title: Fluorinated macrocyclic compounds as hepatitis C virus inhibitors
- Patent Title (中): 氟化大环化合物作为丙型肝炎病毒抑制剂
-
Application No.: US12407461Application Date: 2009-03-19
-
Publication No.: US08372802B2Publication Date: 2013-02-12
- Inventor: Yonghua Gai , Yat Sun Or , Zhe Wang
- Applicant: Yonghua Gai , Yat Sun Or , Zhe Wang
- Applicant Address: US MA Watertown
- Assignee: Enanta Pharmaceuticals, Inc.
- Current Assignee: Enanta Pharmaceuticals, Inc.
- Current Assignee Address: US MA Watertown
- Agency: Elmore Patent Law Group, P.C.
- Agent Edgar W. Harlan; Carolyn S. Elmore, Esq.
- Main IPC: A61K38/00
- IPC: A61K38/00 ; A01N37/18
Abstract:
The present invention discloses compounds of formula I or pharmaceutically acceptable salts, esters, or prodrugs thereof: which inhibit serine protease activity, particularly the activity of hepatitis C virus (HCV) NS3-NS4A protease. Consequently, the compounds of the present invention interfere with the life cycle of the hepatitis C virus and are also useful as antiviral agents. The present invention further relates to pharmaceutical compositions comprising the aforementioned compounds for administration to a subject suffering from HCV infection. The invention also relates to methods of treating an HCV infection in a subject by administering a pharmaceutical composition comprising the compounds of the present invention.
Public/Granted literature
- US20090238794A1 FLUORINATED MACROCYCLIC COMPOUNDS AS HEPATITIS C VIRUS INHIBITORS Public/Granted day:2009-09-24
Information query
IPC分类:
