Invention Grant
- Patent Title: Methods and compositions for the specific inhibition of KRAS by asymmetric double-stranded RNA
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Application No.: US12754427Application Date: 2010-04-05
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Publication No.: US08372816B2Publication Date: 2013-02-12
- Inventor: Bob D. Brown
- Applicant: Bob D. Brown
- Applicant Address: US MA Watertown
- Assignee: Dicerna Pharmaceuticals, Inc.
- Current Assignee: Dicerna Pharmaceuticals, Inc.
- Current Assignee Address: US MA Watertown
- Agency: Edwards Wildman Palmer LLP
- Agent Kathleen Williams
- Main IPC: C12Q1/68
- IPC: C12Q1/68 ; C07H21/04
Abstract:
This invention relates to compounds, compositions, and methods useful for reducing KRAS target RNA and protein levels via use of Dicer substrate siRNA (DsiRNA) agents possessing asymmetric end structures.
Public/Granted literature
- US20110021604A1 METHODS AND COMPOSITIONS FOR THE SPECIFIC INHIBITION OF KRAS BY ASYMMETRIC DOUBLE-STRANDED RNA Public/Granted day:2011-01-27
Information query
