Invention Grant
US08372832B2 1,4-diaza-bicyclo[3.2.2]nonyl oxadiazolyl compounds and their medical use
有权
1,4-二氮杂双环[3.2.2]壬基恶二唑基化合物及其医疗用途
![1,4-diaza-bicyclo[3.2.2]nonyl oxadiazolyl compounds and their medical use](/docs/US/2013-02-12/US08372832B2/abs.jpg.600x600.jpg)
- Patent Title: 1,4-diaza-bicyclo[3.2.2]nonyl oxadiazolyl compounds and their medical use
- Patent Title (中): 1,4-二氮杂双环[3.2.2]壬基恶二唑基化合物及其医疗用途
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Application No.: US13420071Application Date: 2012-03-14
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Publication No.: US08372832B2Publication Date: 2013-02-12
- Inventor: Dan Peters , Gunnar M. Olsen , Elsebet Østergaard Nielsen , Daniel B. Timmermann , Steven Charles Loechel , Jens Damsgaard Mikkelsen , Henrik Björk Hansen , John Paul Redrobe , Jeppe Kejser Christensen , Tino Dyhring
- Applicant: Dan Peters , Gunnar M. Olsen , Elsebet Østergaard Nielsen , Daniel B. Timmermann , Steven Charles Loechel , Jens Damsgaard Mikkelsen , Henrik Björk Hansen , John Paul Redrobe , Jeppe Kejser Christensen , Tino Dyhring
- Applicant Address: DK Ballerup
- Assignee: Neurosearch A/S
- Current Assignee: Neurosearch A/S
- Current Assignee Address: DK Ballerup
- Agency: Birch, Stewart, Kolasch & Birch, LLP
- Priority: DK200600731 20060530
- Main IPC: A61P25/00
- IPC: A61P25/00 ; A61K31/551 ; C07D471/08
![1,4-diaza-bicyclo[3.2.2]nonyl oxadiazolyl compounds and their medical use](/abs-image/US/2013/02/12/US08372832B2/abs.jpg.150x150.jpg)
Abstract:
This invention relates to novel 1,4-diaza-bicyclo[3.2.2]nonyl oxadiazolyl derivatives and their use in the manufacture of pharmaceutical compositions. The compounds of the invention are found to be cholinergic ligands at the nicotinic acetylcholine receptors and modulators of the monoamine receptors and transporters.Due to their pharmacological profile the compounds of the invention may be useful for the treatment of diseases or disorders as diverse as those related to the cholinergic system of the central nervous system (CNS), the peripheral nervous system (PNS), diseases or disorders related to smooth muscle contraction, endocrine diseases or disorders, diseases or disorders related to neuro-degeneration, diseases or disorders related to inflammation, pain, and withdrawal symptoms caused by the termination of abuse of chemical substances.
Public/Granted literature
- US20120172353A1 1,4-DIAZA-BICYCLO[3.2.2]NONYL OXADIAZOLYL COMPOUNDS AND THEIR MEDICAL USE Public/Granted day:2012-07-05
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