Invention Grant
- Patent Title: Co-crystals and pharmaceutical compositions comprising the same
- Patent Title (中): 包含其的共晶体和药物组合物
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Application No.: US13269841Application Date: 2011-10-10
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Publication No.: US08372846B2Publication Date: 2013-02-12
- Inventor: Patrick R. Connelly , Sherry Collier , Michael Tauber
- Applicant: Patrick R. Connelly , Sherry Collier , Michael Tauber
- Applicant Address: US MA Cambridge
- Assignee: Vertex Pharmaceuticals Incorporated
- Current Assignee: Vertex Pharmaceuticals Incorporated
- Current Assignee Address: US MA Cambridge
- Agency: Honigman Miller Schwartz and Cohn
- Agent Kathryn D. Soulier; Jonathan P. O'Brien
- Main IPC: A61K31/4965
- IPC: A61K31/4965
Abstract:
The invention relates to compositions and co-crystals each comprising (1S,3aR,6aS)-2-[(2S)-2-[[(2S)-2-Cyclohexyl-2-(pyrazine-2-carbonylamino)acetyl]amino]-3,3-dimethylbutanoyl]-N-[(3S)-1-(cyclopropylamino)-1,2-dioxohexan-3-yl]-3,3a,4,5,6,6a-hexahydro-1H-cyclopenta[c]pyrrole-1-carboxamide having the structure: and the co-crystal former 4-amino salicylic acid. Also within the scope of this invention are methods of making and using the same.
Public/Granted literature
- US20120088740A1 CO-CRYSTALS AND PHARMACEUTICAL COMPOSITIONS COMPRISING THE SAME Public/Granted day:2012-04-12
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