Invention Grant
- Patent Title: Carboline derivatives useful in the inhibition of angiogenesis
- Patent Title (中): 可用于抑制血管生成的碳氢化合物衍生物
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Application No.: US12715651Application Date: 2010-03-02
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Publication No.: US08372860B2Publication Date: 2013-02-12
- Inventor: Young-Choon Moon , Liangxian Cao , Nadarajan Tamilarasu , Hongyan Qi , Soongyu Choi , William Joseph Lennox , Donald Thomas Corson , Seongwoo Hwang , Thomas Davis
- Applicant: Young-Choon Moon , Liangxian Cao , Nadarajan Tamilarasu , Hongyan Qi , Soongyu Choi , William Joseph Lennox , Donald Thomas Corson , Seongwoo Hwang , Thomas Davis
- Applicant Address: US NJ South Plainfield
- Assignee: PTC Therapeutics, Inc.
- Current Assignee: PTC Therapeutics, Inc.
- Current Assignee Address: US NJ South Plainfield
- Agency: Jones Day
- Priority: WOPCT/US2005/008481 20050315
- Main IPC: A61K31/437
- IPC: A61K31/437 ; C07D471/04
Abstract:
In accordance with the present invention, compounds that inhibit the expression of VEGF post-transcriptionally have been identified, and methods for their use provided. In one aspect of the invention, compounds useful in the inhibition of VEGF production, in the treatment of solid tumor cancer, and in reducing plasma and/or tumor VEGF levels, are provided. In another aspect of the invention, methods are provided for the inhibition of VEGF production, the treatment of cancer, and the reduction of plasma and/or tumor VEGF levels, using the compounds of the invention.
Public/Granted literature
- US20100179132A1 CARBOLINE DERIVATIVES USEFUL IN THE INHIBITION OF ANGIOGENESIS Public/Granted day:2010-07-15
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