Invention Grant
US08372978B2 Salts of methyl 2-((R)-(3-chlorophenyl)((R)-1-((S)-2-(methylamino)-3-((R)-tetrahydro-2H-pyran-3-yl)propylcarbamoyl)piperidin-3-yl)methoxy)ethylcarbamate
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2 - （（R） - （3-氯苯基）（（R）-1 - （（S）-2-（甲基氨基）-3 - （（R） - 四氢-2H-吡喃-3-基） 丙基氨基甲酰基）哌啶-3-基）甲氧基）乙基氨基甲酸酯
- Patent Title: Salts of methyl 2-((R)-(3-chlorophenyl)((R)-1-((S)-2-(methylamino)-3-((R)-tetrahydro-2H-pyran-3-yl)propylcarbamoyl)piperidin-3-yl)methoxy)ethylcarbamate
- Patent Title (中): 2 - （（R） - （3-氯苯基）（（R）-1 - （（S）-2-（甲基氨基）-3 - （（R） - 四氢-2H-吡喃-3-基） 丙基氨基甲酰基）哌啶-3-基）甲氧基）乙基氨基甲酸酯
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Application No.: US12851267Application Date: 2010-08-05
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Publication No.: US08372978B2Publication Date: 2013-02-12
- Inventor: David A. Claremon , Robert D. Simpson , Lanqi Jia
- Applicant: David A. Claremon , Robert D. Simpson , Lanqi Jia
- Applicant Address: US PA Fort Washington
- Assignee: Vitae Pharmaceuticals, Inc.
- Current Assignee: Vitae Pharmaceuticals, Inc.
- Current Assignee Address: US PA Fort Washington
- Agency: Hamilton, Brook, Smith & Reynolds, P.C.
- Main IPC: A61K31/453
- IPC: A61K31/453 ; C07D413/12 ; A61P9/00
Abstract:
Mucic acid salts of a compound represented by the following structural formula: are disclosed. In particular, single crystalline mucic acid salts of the compound represented by structural formula (I) are characterized by a variety of properties and physical measurements. Methods of producing the mucic acid salts, using the salts to antagonize one or more aspartic proteases, and methods of treating a number of aspartic protease mediated disorders using the salts are described herein.
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