Invention Grant
- Patent Title: Ribonucleotide reductase inhibitors and methods of use
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Application No.: US13364263Application Date: 2012-02-01
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Publication No.: US08372983B2Publication Date: 2013-02-12
- Inventor: David Horne , Christopher Lincoln
- Applicant: David Horne , Christopher Lincoln
- Applicant Address: US CA Duarte
- Assignee: City Of Hope
- Current Assignee: City Of Hope
- Current Assignee Address: US CA Duarte
- Agency: Perkins Coie LLP
- Agent Patrick D. Morris
- Main IPC: C07D277/46
- IPC: C07D277/46
Abstract:
Provided herein are novel compounds that inhibit ribonucleotide reductase (RR) by binding to RRM2 and interfering with the activity of the RRM1/RRM2 holoenzyme, as well as methods of synthesizing these novel compounds. The compounds may be used to inhibit RR activity and to treat various conditions associated with RRM2 expression, such as for example certain cancer types, mitochondrial diseases, or degenerative diseases.
Public/Granted literature
- US20120253048A1 RIBONUCLEOTIDE REDUCTASE INHIBITORS AND METHODS OF USE Public/Granted day:2012-10-04
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