Invention Grant
- Patent Title: Dual-acting oxazole antihypertensive agents
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Application No.: US12835999Application Date: 2010-07-14
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Publication No.: US08372984B2Publication Date: 2013-02-12
- Inventor: Paul R. Fatheree , Ryan Hudson , Robert Murray McKinnell
- Applicant: Paul R. Fatheree , Ryan Hudson , Robert Murray McKinnell
- Applicant Address: US CA South San Francisco
- Assignee: Theravance, Inc.
- Current Assignee: Theravance, Inc.
- Current Assignee Address: US CA South San Francisco
- Agent Jeffrey A. Hagenah; Shelley Eberle
- Main IPC: A61K31/422
- IPC: A61K31/422 ; A61K31/421 ; A61K31/4439 ; A61K31/5377 ; A61K31/4245 ; A61K31/497 ; A61K31/506 ; A61K31/5575 ; C07D413/10 ; C07D263/34 ; C07D413/14 ; C07D413/06 ; A61P9/12

Abstract:
In one aspect, the invention relates to compounds having the formula: wherein: Ar, Z, R3, R4 and R5 are as defined in the specification, or a pharmaceutically acceptable salt thereof. These compounds have AT1 receptor antagonist activity and neprilysin inhibition activity. In another aspect, the invention relates to pharmaceutical compositions comprising such compounds; methods of using such compounds; and process and intermediates for preparing such compounds.
Public/Granted literature
- US20110021527A1 DUAL-ACTING OXAZOLE ANTIHYPERTENSIVE AGENTS Public/Granted day:2011-01-27
Information query
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