The present invention provides a safety device for cutting off high voltage for a hybrid electric vehicle, which cuts off the connection between an interlock pin and a battery management system to cut off the current flow after electric power is supplied from a high voltage battery, thus preventing the occurrence of arc when an external connected is disconnected.For this purpose, the present invention provides a safety device for cutting off high voltage for a hybrid electric vehicle, the safety device including: a male housing including a guide hole formed on the bottom thereof; a female housing into which the male housing is inserted; a cover including a projection formed on the bottom thereof to rotate along the guide hole; a locker connected to the projection and rotating along the guide hole; and an interlock housing including an interlock pin attached to the bottom thereof and moving up and down in the rotational direction of the locker to control the current flow between the interlock pin and a battery management system, thus preventing the occurrence of arc when an external connector is disconnected.