A method for updating two or more regions of the display area of a bistable, electro-optic display device comprises selecting at least one first waveform for at least one pixel of a first region; (b) selecting at least one second waveform for at least one pixel of a second region; (c) updating the first region by generating and providing the first waveform to the at least one pixel of the first region; and (d) updating the second region by generating and providing the second waveform to the at least one pixel of the second region, wherein the first and second updates at least partially coincide in time. The first waveform is selected from a first drive scheme for use in a first update mode having a first period. The second waveform is selected from second a drive scheme for use in a second update mode having a second period.