An isolation gown is provided and includes a body cover portion that is open near the knee area of the wearer. The gown includes two sleeves, wherein each of the sleeves is configured to cover a wearer's arm and terminate in an arm opening located proximate a wearer's wrist, such that each arm of the wearer is covered by the sleeves to an area proximate the wearer's wrist, wherein each of the arm openings includes a continuous elastic portion surrounding the arm opening to resiliently contact the wearer's arm, and a collar defining a neck opening, wherein the collar defines a collar opening and includes a configurable connecting article to close the collar opening, wherein each of the body cover portion and the two sleeves are constructed from a material impervious to liquids.