An integrated sensor and self defense system for large aircraft incorporates a forward looking missile warning sensor (MWS) mounted in a replacement panel for mounting in an un-pressurized aft compartment, an aft looking MWS mounted in the panel substantially adjacent the forward looking MWS, and a laser system for engaging a missile detected by an MWS mounted proximate the forward and aft looking MWS. A processor and electronics for controlling said MWS and laser systems are mounted adjacent the active components with indicators and operator control systems mounted in the aircraft cockpit.