A wheel safeguard assembly installed on a bottom of a main body of a two-wheeled vehicle includes: two guide columns attached on respective sides of a rear end of the main body; a base disposed across the rear end of the main body and behind a rear wheel of the vehicle; two rollers pivoted on respective sides of the base; two rotatable linkages, one end of each linkage pivoted to the respective side of the rear end, and another end of each linkage pivoted to the respective side of the base adjacent to the rollers; two guide slots formed in the respective sides of the base and the guide columns disposed in respective guide slots.