The invention relates to a two-chamber syringe device comprising a cylinder element (2), a closure element (6), two plungers (3) and (4) and optionally an intermediate plunger (3a), wherein one or more fluid-tight, gas-permeable membranes (8) and optionally valve membranes (15) are arranged in the wall of the cylinder element (2) or in the closure element (6), allowing gas in the chambers to escape from the cylinder element (2) when the plungers (3), (3a) and (4) are displaced in the distal direction.