A feeding set for a peristaltic pump system includes a cassette configured for releasable connection thereto. A deflectable lumen priming actuator is formed integrally with the cassette for conjoint connection to and disconnection from the pump system with the cassette as a single unit. The priming actuator includes an actuation pad and is moveable from a rest position to a deflected position. A substantially flexible lumen is coupled to the cassette. The lumen has an inlet, an outlet, and an extensible peristalsis loop. An inline valve is received within the lumen. The inline valve is arranged to obstruct fluid flow through the lumen. The actuation pad of the priming actuator is located proximate the inline valve in the rest position and is adapted to contact and apply a force to the lumen adjacent the inline valve when the priming actuator is moved to the deflected position. The force applied to the lumen is sufficient to establish at least one flow channel between the inline valve and the lumen.