Invention Grant
US08377418B2 Process for preparing thermosensitive (poly(ethylene oxide) poly(propylene oxide)) derivatives that can be used to functionalize chitosan
有权
用于制备可用于官能化壳聚糖的热敏（聚（环氧乙烷）聚（环氧丙烷））衍生物的方法
- Patent Title: Process for preparing thermosensitive (poly(ethylene oxide) poly(propylene oxide)) derivatives that can be used to functionalize chitosan
- Patent Title (中): 用于制备可用于官能化壳聚糖的热敏（聚（环氧乙烷）聚（环氧丙烷））衍生物的方法
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Application No.: US12677211Application Date: 2008-09-11
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Publication No.: US08377418B2Publication Date: 2013-02-19
- Inventor: Rachel Auzely-Velty , Caroline Creuzet
- Applicant: Rachel Auzely-Velty , Caroline Creuzet
- Applicant Address: FR Paris FR St. Martin d'Heres
- Assignee: Centre National de la Recherche Scientifique (CNRS),Universite Joseph Fourier-Grenoble 1
- Current Assignee: Centre National de la Recherche Scientifique (CNRS),Universite Joseph Fourier-Grenoble 1
- Current Assignee Address: FR Paris FR St. Martin d'Heres
- Agency: Foley & Lardner LLP
- Priority: FR0757506 20070911
- International Application: PCT/EP2008/062059 WO 20080911
- International Announcement: WO2009/034130 WO 20090319
- Main IPC: A61K51/00
- IPC: A61K51/00 ; A61K36/14 ; A61K9/22 ; C08B37/08
Abstract:
The invention relates to a thermosensitive (poly(ethylene oxide) poly(propylene oxide))-acetal derivative, which can be used to functionalize chitosan, and to the process for the preparation thereof. The invention therefore also relates to a process for functionalizing chitosan by grafting this thermosensitive copolymer and optionally another thermosensitive polymer, poly(ethylene oxide). A subject of the invention is also a chitosan-(poly(ethylene oxide) poly(propylene oxide))-poly(ethylene oxide) derivative which has the advantage of being water-soluble at physiological pH. The invention therefore also relates to the aqueous compositions comprising this derivative and to the use of this composition for the manufacture of gel by heating.
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