Invention Grant
US08377954B2 Bicyclic spiropiperidine beta-secretase inhibitors for the treatment of Alzheimer's disease
有权
双环哌啶哌啶β-分泌酶抑制剂用于治疗阿尔茨海默病
- Patent Title: Bicyclic spiropiperidine beta-secretase inhibitors for the treatment of Alzheimer's disease
- Patent Title (中): 双环哌啶哌啶β-分泌酶抑制剂用于治疗阿尔茨海默病
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Application No.: US12522056Application Date: 2007-12-28
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Publication No.: US08377954B2Publication Date: 2013-02-19
- Inventor: Shaun R. Stauffer , Samuel L. Graham
- Applicant: Shaun R. Stauffer , Samuel L. Graham
- Applicant Address: US NJ Rahway
- Assignee: Merck, Sharp & Dohme, Corp
- Current Assignee: Merck, Sharp & Dohme, Corp
- Current Assignee Address: US NJ Rahway
- Agent Keith D. MacMillan; Gerard M. Devlin
- International Application: PCT/US2007/026469 WO 20071228
- International Announcement: WO2008/085509 WO 20080717
- Main IPC: C07D401/14
- IPC: C07D401/14 ; A61K31/438
Abstract:
The present invention is directed to bicyclic spiropiperidine compounds of formula (I) which are inhibitors of the beta-secretase enzyme and that are useful in the treatment of diseases in which the beta-secretase enzyme is involved, such as Alzheimer's disease. The invention is also directed to pharmaceutical compositions comprising these compounds and the use of these compounds and compositions in the treatment of such diseases in which the beta-secretase enzyme is involved.
Public/Granted literature
- US20100076004A1 BICYCLIC SPIROPIPERIDINE BETA-SECRETASE INHIBITORS FOR THE TREATMENT OF ALZHEIMER'S DISEASE Public/Granted day:2010-03-25
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