An object of the present invention is, in a thermoplastic elastomer composition in which a modified rubber is filled and dispersed in a polyamide resin matrix in order to improve the low-temperature durability of the polyamide resin, to reduce the extrusion load during extrusion molding thereof into a film without deteriorating the low-temperature durability. The present invention is a thermoplastic elastomer composition (E) comprising a modified polyamide resin (C) and a modified rubber (D) dispersed in the modified polyamide resin (C), the modified polyamide resin (C) being a resin obtained by melt-blending an polyamide resin (A) and a compound (B) capable of reacting with a terminal amino group of a polyamide resin, wherein the modified rubber (D) has an acid anhydride group or epoxy group and is dynamically cross-linked by a compound (F) having at least one disulfide bond and at least two amino groups. This thermoplastic elastomer composition can be suitably used in the production of an inner liner of a pneumatic tire.