Invention Grant
- Patent Title: Peptides for the regulation of neurotransmitter sequestration and release
- Patent Title (中): 用于调节神经递质螯合和释放的肽
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Application No.: US12450076Application Date: 2008-03-12
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Publication No.: US08378070B2Publication Date: 2013-02-19
- Inventor: Nirit Lev , Daniel Offen , Eldad Melamed
- Applicant: Nirit Lev , Daniel Offen , Eldad Melamed
- Applicant Address: IL Tel-Aviv
- Assignee: Ramot at Tel-Aviv University Ltd.
- Current Assignee: Ramot at Tel-Aviv University Ltd.
- Current Assignee Address: IL Tel-Aviv
- International Application: PCT/IL2008/000336 WO 20080312
- International Announcement: WO2008/111063 WO 20080918
- Main IPC: A61K38/00
- IPC: A61K38/00 ; A61K38/18 ; A61P25/00 ; A61P25/28
Abstract:
A method of selecting an agent comprising a neuroprotecting activity is disclosed. The method comprises: (a) introducing a plurality of agents into a plurality of cells; and (b) analyzing Vesicular Monoamine Transporter 2 (VMAT2) transcription in the cells; and (c) identifying an agent of the plurality of agents capable of up-regulating DJ-1-dependent VMAT2 transcription in the cells, thereby selecting the agent comprising the neuroprotectingactivity.
Public/Granted literature
Information query
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