Invention Grant
- Patent Title: Synthesis of acyloxyalkyl carbamate prodrugs and intermediates thereof
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Application No.: US13208176Application Date: 2011-08-11
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Publication No.: US08378137B2Publication Date: 2013-02-19
- Inventor: Mark A. Gallop , Xuedong Dai , Randall A. Scheuerman , Stephen P. Raillard , Suresh K. Manthati , Fenmei Yao , Thu Phan , Maria Ludwikow , Ge Peng , Seema Bhat
- Applicant: Mark A. Gallop , Xuedong Dai , Randall A. Scheuerman , Stephen P. Raillard , Suresh K. Manthati , Fenmei Yao , Thu Phan , Maria Ludwikow , Ge Peng , Seema Bhat
- Applicant Address: US CA Santa Clara
- Assignee: XenoPort, Inc.
- Current Assignee: XenoPort, Inc.
- Current Assignee Address: US CA Santa Clara
- Agency: Dorsey & Whitney LLP
- Main IPC: C07C271/22
- IPC: C07C271/22 ; C07C269/00 ; C07D207/46
Abstract:
Methods for synthesis of 1-(acyloxy)-alkyl carbamates, particularly, the synthesis of 1-(acyloxy)-alkyl carbamate prodrugs of primary or secondary amine-containing drugs are described. Also described are methods for synthesis of 1-(acyloxy)-alkyl N-hydroxysuccinimidyl carbonates which are useful intermediates in the synthesis of 1-(acyloxy)-alkyl carbamates are also described.
Public/Granted literature
- US20120010425A1 SYNTHESIS OF ACYLOXYALKYL CARBAMATE PRODRUGS AND INTERMEDIATES THEREOF Public/Granted day:2012-01-12
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