Invention Grant
- Patent Title: Methods of making Efavirens and intermediates thereof
- Patent Title (中): 依法韦仑及其中间体的制备方法
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Application No.: US13330381Application Date: 2011-12-19
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Publication No.: US08378143B2Publication Date: 2013-02-19
- Inventor: Bo Chen , Zhi-Xian Wang , Yutao Xue , Lihong Liu , Hao Chen
- Applicant: Bo Chen , Zhi-Xian Wang , Yutao Xue , Lihong Liu , Hao Chen
- Applicant Address: CA Brantford
- Assignee: Apotex Pharmachem Inc.
- Current Assignee: Apotex Pharmachem Inc.
- Current Assignee Address: CA Brantford
- Main IPC: C07C233/54
- IPC: C07C233/54
Abstract:
The present invention provides a process for the preparation of Efavirenz. A compound of Formula 1: may be prepared by a process comprising cyclizing, in the presence of a first base, a compound of Formula 5 with a haloformate of Formula 6. Other processes are also provided as well as novel compounds prepared by and used in such processes.
Public/Granted literature
- US20120095249A1 METHODS OF MAKING EFAVIRENS AND INTERMEDIATES THEREOF Public/Granted day:2012-04-19
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