A bulk-driven current-sense amplifier and an amplifier operating method are disclosed. The bulk-driven current-sense amplifier includes a differential amplifier, a first driver, and a second driver. The first driver is coupled to the differential amplifier, and a first node is formed at a connectivity segment of the first driver. The second drive is coupled to the differential amplifier, and a second node is formed at a connectivity segment of the second driver. When a first switch of the first driver and a second switch of the second driver are turned on, the differential amplifier charges the first node and the second node. When the charging is completed, the first node and the second node respectively have a different stabilized potential according to currents separately flowing through a first memory unit of the first driver and a second memory unit of the second drive, and the differential amplifier generates a voltage.