An apparatus and method for assisting medication are capable of assisting medication of users who have to regularly take medications in daily life. The apparatus includes a medication box having a plurality of containers, each of which stores a dose of medication to be taken at one time according to a medication schedule, a radio frequency (RF) transmitter carried on a user and transmitting an RF signal, an RF receiver receiving the RF signal from the RF transmitter, and a controller controlling medication assisting. Thus, the apparatus checks a spatial-temporal situation of the user, i.e. an medication, notification or information situation, using the received RF signal, and creating and providing medication service corresponding to the checked situation.