The present invention relates to a method and apparatus for estimating a channel in a mobile communication network. In particular, the present invention relates to a method of estimating a channel under a channel environment where interference between neighboring base stations exists in a mobile communication network using an orthogonal frequency division multiplexing (OFDM) method. In order to estimate a channel, one cluster is divided into two sub-clusters, and pilot sub-carrier signals included in at least one sub-cluster in an OFDM symbol direction are used. Therefore, it is possible to further improve performance as compared to a method of estimating a channel by using pilot sub-carriers included in one cluster.