A method of transmitting a data sequence between a sender and a receiver over a wireless link. The method comprises, at the sender, segmenting the data sequence into a plurality of data segments and, for each segment, constructing a frame containing as payload the data segment, transmitting the frame across the wireless link, and receiving an acknowledgement or non-acknowledgement from said receiver for the frame, and only upon receipt of such acknowledgement or non-acknowledgement, retransmitting the frame or transmitting a further frame containing as payload the next data segment.