An easy lock and release mechanism for a safety seat retaining on a stroller frame and a base. A front confinement is mounted on the stroller frame, and has a spring-loaded latch retractively protruding from a rear wall of the front confinement for locking the safety seat. The safety seat has two anchoring slots, at least a downward holding slot and two latching elements. The downward holding slot has an orifice formed therein for engaging with the spring-loaded latch. The two anchoring slots may anchor to two transversal bars on the base and be locked by the two latching elements. The release mechanism is mounted on the safety seat, and has a release actuator associated with a pushing element and the two latching elements for pushing the spring-loaded latch away from the orifice and unlock the two latching elements.