A rapid-engaging, positive locking machine screw mechanism comprises a screw having a head and a body wherein the body includes male threads formed thereon wherein the threaded body has at least one longitudinal segment devoid of threads. A work piece defines a hole having female threads formed therein for receiving the screw and further defines in a portion of the hole, at least one longitudinally extending segment devoid of female threads. The longitudinal screw segment devoid of male threads and the longitudinal hole segment devoid of female threads are arranged such that the screw body is longitudinally received in the hole without engagement of the male screw threads with the female work piece threads. The rapid-engaging, positive locking thread configuration can be applied to a variety of mechanical interfaces. Additionally, thread locking configurations, such as a boos-depression interface, a notch and ridge, etc. can be incorporated to secure the male and female threads.