Invention Grant
- Patent Title: Nicotinamide riboside kinase compositions and methods for using the same
- Patent Title (中): 烟酰胺核苷激酶组合物及其使用方法
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Application No.: US13445289Application Date: 2012-04-12
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Publication No.: US08383086B2Publication Date: 2013-02-26
- Inventor: Charles M. Brenner
- Applicant: Charles M. Brenner
- Applicant Address: US NH Hanover
- Assignee: Trustees of Dartmouth College
- Current Assignee: Trustees of Dartmouth College
- Current Assignee Address: US NH Hanover
- Agency: Licata & Tyrrell P.C.
- Main IPC: A61K38/45
- IPC: A61K38/45 ; A61K31/7088 ; C07H17/00 ; A61P35/00
Abstract:
The present invention relates to isolated nicotinamide riboside kinase (Nrk) nucleic acid sequences, vectors and cultured cells containing the same, and Nrk polypeptides encoded thereby. Methods for identifying individuals or tumors susceptible to nicotinamide riboside-related prodrug treatment and methods for treating cancer by administering an Nrk nucleic acid sequence or polypeptide in combination with a nicotinamide riboside-related prodrug are also provided. The present invention further provides screening methods for isolating a nicotinamide riboside-related prodrug and identifying a natural source of nicotinamide riboside.
Public/Granted literature
- US20120251463A1 Nicotinamide Riboside Kinase Compositions and Methods for Using the Same Public/Granted day:2012-10-04
Information query
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