Invention Grant
- Patent Title: Fusion of peptidoglycan hydrolase enzymes to a protein transduction domain allows eradication of both extracellular and intracellular gram positive pathogens
- Patent Title (中): 肽聚糖水解酶融合蛋白转导结构域可以消除细胞外和细胞内革兰氏阳性病原菌
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Application No.: US12784675Application Date: 2010-05-21
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Publication No.: US08383102B2Publication Date: 2013-02-26
- Inventor: David Donovan
- Applicant: David Donovan
- Applicant Address: US DC Washington
- Assignee: The United States of America as represented by the Secretary of Agriculture
- Current Assignee: The United States of America as represented by the Secretary of Agriculture
- Current Assignee Address: US DC Washington
- Agent John D. Fado; Evelyn M. Rabin
- Main IPC: A61K38/54
- IPC: A61K38/54 ; C07H21/04 ; C12N15/63 ; C12N5/10
Abstract:
Lysostaphin is a bacteriocin secreted by S. simulans to kill S. aureus, and has been shown to also be a potent antimicrobial for many antibiotic-resistant strains of S. aureus. By adding a ˜13 amino acid protein transduction domain (PTD) from the HIV-TAT protein to lysostaphin to form lysostaphin-PTD, both extracellular and intracellular forms of S. aureus and MRSA are killed in all (multiple) cell types examined.
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